WILLIAM B. MACAULAY, MD

Research

  • 2005 - Present
    Advisory Dean of Students
    College of Physicians and Surgeons, Columbia University


  • 2001 - Present
    Director
    Center for Hip & Knee Replacement New York Presbyterian Hospital at Columbia University, New York, NY


  • 1999 – 2000
    Adjunct Scientist
    Hospital for Special Surgery, New York, NY


  • 1998 – 1999
    Research Fellow
    Mineralized Tissue Group, Hospital for Special Surgery, New York, NY
    Mentors: Adele Boskey, EA Salvati, and TP Sculco
    Studied: 1) Biochemical markers of fibrinolysis in patients after THA 2) Designed, synthesized and patented novel osteoblast adhesive pepitides with potential use in tissue engineering, etc


  • 1993 – 1994
    Resident Research Fellow
    Musculoskeletal Research Center (MSRC)
    Mentors: Christopher Evans, PhD and Harry Rubash, MD, Musculoskeletal Institute, UPMC, Pittsburgh, PA
    Studied: 1) Gene therapeutics for rheumatoid arthritis 2) Canine Model for THA 3) Peri-acetabular debris migration in THA and 4) Nitric oxide's role in aseptic loosening


  • 1990 – 1992
    Medical Student Researcher
    Orthopaedic Research Laboratory College of Physicians & Surgeons Columbia University; New York, NY
    Mentors: Anthony Ratcliffe, PhD and Van Mow, PhD Studied potential biochemical markers of osteoarthritis and developed an improved sandwich ELISA for keratan sulfate


  • 1989
    Dean's Research Fellow
    College of Physicians & Surgeons Columbia University
    Mentor: Samuel Silverstein, MD, Completed pilot project examining cytoplasmic peptide fragment transport/presentation in J774 murine macrophages


  • 1986 – 1988
    Research Assistant
    Dept. of Biochemistry, The Rockefeller University, New York, NY
    Mentor: R.B. Merrifield, PhD (Nobel Prize in Chemistry 1984) Synthesized analogs of glucagon via solid phase methodology, Purified these products via self-designed preparative HPLC set-up, and studied structure/function relationships via circular dichroism, biological assays and molecular modeling


  • 1985 – 1986
    Research Fellow
    Dept. of Biochemistry, Trinity College
    Mentor: Richard Crawford, PhD Developed an assay scheme to determine the relative tyrosine hydroxylation activity of tyrosinase and tyrosine hydroxylase within a crude tissue homogenate
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